Product Description

BI 456906-S (Survodutide)

Product Overview

BI 456906, also known as survodutide, is an investigational synthetic peptide designed to activate both the glucagon-like peptide-1 receptor (GLP-1R) and the glucagon receptor (GCGR). It is a modified, long-acting peptide developed to investigate the complementary roles of these signaling pathways in energy balance, glucose regulation, and metabolic function.

Activation of GLP-1 receptors is associated with pathways involved in appetite regulation, food intake, and gastric emptying. Glucagon receptor activation influences energy expenditure and hepatic metabolic processes. By targeting both receptors, survodutide is being investigated for its potential role in metabolic research, including studies of obesity and metabolic dysfunction-associated steatohepatitis (MASH), formerly known as non-alcoholic steatohepatitis (NASH).

Preclinical studies have demonstrated activity at both receptors, while early-stage human clinical trials have examined safety, tolerability, pharmacokinetics, and metabolic outcomes. Survodutide remains investigational, and its clinical development findings should not be interpreted as establishing the safety or efficacy of research-grade products or unapproved formulations.

Key Research Areas

GLP-1 receptor and glucagon receptor signaling pathways

Appetite regulation, food intake, and energy balance research

Glucose homeostasis and metabolic regulation

Hepatic metabolism and liver-related research models

Dual-receptor agonism and peptide structure–activity relationships

Pharmacokinetics, peptide stability, and analytical characterization

Handling & Reconstitution

For laboratory use, reconstitute with Bacteriostatic Water (BAC) or sterile saline. After reconstitution, the solution should be stored at 2–8°C (36–46°F) and used within the appropriate experimental window to maintain peptide stability.