G2-T 5MG

Product Description

Tirz (Dual Agonist)

Product Overview

Tirz is a synthetic peptide and a first-in-class "twincretin" that functions as a dual agonist of the glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors. It is composed of a 39-amino acid sequence based on the endogenous GIP peptide, modified with a C20 fatty diacid moiety to significantly extend its metabolic half-life and potency. By engaging both the GIP and GLP-1 pathways, Tirzepatide allows for high-level research into the synergistic effects of multi-incretin activation on glucose-dependent insulin secretion and systemic metabolic regulation.

Key Research Areas

Dual-Incretin Synergy: Investigating the co-activation of GIPR and GLP-1R and its impact on postprandial glucose homeostasis.

Pancreatic Somatotropic Function: Evaluating the peptide's role in enhancing beta-cell function and insulin biosynthesis in animal models.

Lipid Metabolism: Researching the influence of GIP receptor activation on white adipose tissue and systemic lipid oxidation.

Satiety Signaling: Assessing the dual mechanisms of delayed gastric emptying and central appetite suppression in metabolic research.

Handling & Reconstitution

For laboratory evaluation, reconstitute with Bacteriostatic Water (BAC). To maintain the structural integrity of the C20 fatty acid chain, avoid vigorous agitation or vortexing during the reconstitution process. Once reconstituted, store at 2–8°C (36–46°F) and utilize within the recommended experimental timeframe.

Researched for Gastrointestinal & Immune Barrier